Rabbit DQ52 and DH gene expression in early B-cell development
HT Chen, CB Alexander, FF Chen, RG Mage - Molecular immunology, 1996 - Elsevier
Rabbits predominantly rearrange the most 3′ VH gene (VH1); thus combinatorial diversity
is very limited. In man and mouse, the most 3′ DH gene, DQ52, is preferentially rearranged
early in B-cell development. To test whether this preference for rearranging a DH gene
segment based on 3′ end proximity exists in rabbit, we cloned and sequenced the rabbit
DQ52 gene. The 11 base pair coding region sequence is identical to a published mouse
DQ52, and 81.8% similar to the human sequence. It is localized∼ 805 bp upstream of the …
is very limited. In man and mouse, the most 3′ DH gene, DQ52, is preferentially rearranged
early in B-cell development. To test whether this preference for rearranging a DH gene
segment based on 3′ end proximity exists in rabbit, we cloned and sequenced the rabbit
DQ52 gene. The 11 base pair coding region sequence is identical to a published mouse
DQ52, and 81.8% similar to the human sequence. It is localized∼ 805 bp upstream of the …
[引用][C] Rabbit DQ52 and DH gene expression in early B-cell development.
C HuaTang, CB Alexander, C FeiFei, RG Mage - Molecular Immunology, 1996
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